Joseph G. Cacchione, MD, FACC

In 2022, Dr. Cacchione was appointed CEO of Jefferson, an expansive enterprise encompassing Jefferson Health, Thomas Jefferson University, and Jefferson Health Plans which annually serves millions of patients, 8,300 students, and more than 350,000 insurance members across Pennsylvania and New Jersey.

Dr. Cacchione has shepherded Jefferson through a period of remarkable growth and post-pandemic financial recovery. In 2024 he spearheaded a landmark merger with Lehigh Valley Health Network which transformed Jefferson into a $15 billion health system with 65,000 employees, positioning it among the top 15 non-profit health systems in the nation.

Before his tenure at Jefferson, Dr. Cacchione was the Executive Vice President of Clinical and Network Services at Ascension, one of the largest private healthcare systems in the U.S. There, he helped steer a $28 billion organization with 165,000 employees spanning 145 hospitals and over 2,600 care sites across 19 states and the District of Columbia. Prior to this role, he served as the CEO of Ascension Michigan, overseeing 15 hospitals and 22,000 employees.

Dr. Cacchione's journey before Ascension was marked by his eight-year tenure at the Cleveland Clinic where he served as Chairman of Operations and Strategy for its Heart and Vascular Institute. Earlier, he was the Executive Vice President and Chief of Quality & Operations at Saint Vincent’s Health System in Erie, PA.

Dr. Cacchione is Board Certified in internal medicine, cardiovascular disease, and interventional cardiology. He holds active medical licenses in Ohio, New York, and Pennsylvania.